Getting poster data...
Adin Aoki, Carlos Ayala, Lynn Agre, Rachana Tyagi, Wise Young (604 Allison Rd, Piscataway, NJ 08854)Approximately 80% of spinal cord injuries (SCI) occur in men. Women recover significantly better walking than men after SCI, suggesting gender mechanisms affecting SCI outcome. Secondary Injury, or progressive tissue damage after injury, may differ in males and females. Fischer 344 (F344) SCI rat models display significant time-dependent gender effects in circulating neutrophils during the first week after injury. Neutrophils have yet to be counted in situ in the injured cord using immunohistochemistry confocal imaging. Among clinical literature investigating SCI in humans, there are few published effects of gender. This poster investigates effects of gender, with interdisciplinary focus on both acute animal and human SCI neuroimmune responses. To determine effects in humans, 176 SCI patient records from Robert Wood Johnson University Hospital (RWJUH) were downloaded, recoded, and statistically analyzed. Animal findings await the finalization of a paraffin immunohistochemistry staining method. In humans, gender appears to have significant effects the first 24 hours after injury on white blood cell (WBC) response. Further investigation may isolate novel therapeutic mechanisms.