Getting poster data...
Gustavo Salazar, Lorna Richardson, Neil Rawlings, Robert Finn (European Bioinformatics Institute)Automatic annotation of genomes is a necessary step towards the understanding of newly sequenced species. The InterPro database combines the prediction models of 14 member resources, including TIGRFAM and Pfam. InterProScan matches sequence regions with protein families and domains in the InterPro database, making it an important tool in the annotation of new genomes. The concept of a Genome Property (GP) was introduced by TIGRFAM as a method to improve the functional annotation of prokaryotic genomes. In the simplest terms, it maps TIGRFAM or Pfam models to the required set of proteins in a biochemical reaction, in particular the steps in a pathway. Using this mapping, it is possible to infer the presence or absence of such metabolic steps in any given sequence. We created a pipeline that uses InterProScan to calculate the presence of the GPs in a given genome sequence, and ran this pipeline on a reference set of 217 species. The Genome Properties Viewer assists in the visual exploration of these pipeline results, allowing the user to focus on genomes or pathways of interest. Further, it allows the comparison of user-defined proteomes with these reference proteome sets.