Getting poster data...
Graham Ritchie (Wellcome Trust Sanger Institute, Cambridge, United Kingdom)Functional annotation of genomic sequence is substantially based on evaluation of the alignment of sequence data from many sources to produce a coherent picture of genomic features. Recent advances intechnology mean that the amount of data available for evaluation is becoming impossible to view using current software. Solving this requires a mixture of better techniques for filtering and summarising the data combined with faster more dynamic approaches for display. To achieve this the Otterlace/ZMap system has separated display from curation: ZMap is a database-independent multi-threaded program written in C to give good display performance. Otterlace is a curation program (and associated pipelines) which because it is written in perl can be rapidly altered to respond to changes in data whether by direct modification or by making use of the new bioinformatics packages. ZMap is controlled by Otterlace using a simple protocol that allows the two programs to present a unified annotation interface to the curator giving the them the best of both worlds: performance and flexibility. The interface includes operations to load and merge data on request so that only the features the curator