Getting poster data...
Björn Sommer (Bielefeld University, Bielefeld, Germany)The aim of CELLmicrocosmos (Cm) is to develop tools to create virtual cell environments following a top-down approach: Abstract cell representations designed as interpretations of microscopic images are used to visualize, explore and analyse cells to support the understanding of their internal structures and their functioning. The localization of enzymes on the cellular and sub-compartmental level is introduced by the concept of the PathwayIntegration (CmPI). Cell components are spatially correlated with metabolic pathways derived from KEGG (Kyoto Encyclopedia of Genes and Genomes) by using (un-)reviewed references from different databases. To integrate enzymes on the molecular level, we developed the MembraneEditor (CmME) working with Protein Data Bank (PDB) models. It can be used for generating 3D membranes by using lipid compositions derived from literature, for semi-automatic protein placement and for exporting initial membranes compatible to simulation environments. Future aims are the correlation of the cell environment with generated membrane structures and 3D Microscopy based cell components.