Getting poster data...
Fabrice Jossinet (University of Strasbourg, Strasbourg, France)It is now fully recognized that RNA molecules play key roles at all stages of cell life. An increasing number of research projects is confronted to the study of coding and non-coding structured RNA genes. Consequently, several tasks are becoming recurrent: consensus structure predictions, constructions of 3D models, searches in genomes for new RNA candidates,... Since the biological function of RNA molecules is linked to their ability to establish complex and dynamic 3D architectures, a prerequisite of these tasks is the availability of high quality alignments in terms of both sequence and structure (a.k.a. "structural alignments"). In general, precomputed RNA alignments need to be corrected or refined by hand, which is a complex and time-consuming step. Today, only few alignment editors are adapted to RNA peculiarities. Among them, S2S is a semi-automated tool providing unique graphical features. It allows the alignment of a set of orthologous RNA sequences against a reference one for which a solved tertiary structure is available. Once loaded, S2S communicates with WebServices to deduce from this tertiary structure the set of base-base interactions stabilizing it. These interacti