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Kim Kristiansen (Glostrup Research Institute, Glostrup, Denmark)Aspects of the neurovascular disease migraine are studied through the use of confocal microscopy and RT-PCR, aiming to describe signalling pathways involved in the trigeminovascular system in order to better understand the pathophysiology of migraine. Current research focuses on up/down regulation of pro- and anti-inflammatory cytokines. Inflammation is the immune systems response to harmful stimuli and as such considered to be involved in primary headaches. Calcitonin gene-related peptide is a major constituent in the trigeminovascular pathway, and putatively plays a part in inflammation. The inflammation is most likely associated with an increase in expression of various cytokines such as Interleukin 1-B, IL6 and IL10. The overall cytokine involvement in trigeminovascular inflammation is still unclear but these chemical regulators are thought to be involved in migraine attacks. We use immunohistochemistry in combination with RT-PCR to study interactions between satellite glial cells and neurons in the rat TGG from fresh and organ cultured tissue.