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Damien Larivière (Fourmentin-Guilbert Scientific Foundation, Noisy-Le-Grand, France)Thanks to NMR, X-ray crystallography and electron microscopy, it is possible to resolve the 3D structure of many cell components. While software exist for visualizing the 3D shape of individual biological molecules, a visual discovery tool is needed to link individual components within a system view . Setting proteins back into their cellular context (finite volume, finite number of components) gives rise to new questions. It leads biologists to formulate experimentally testable hypothesis regarding which conformation (scale of protein cluster) and organization (scale of the cell) support a cellular process in a crowded medium. The benefit of spatial modelling and visualization is likewise to measure architectural parameters in order to refine computational models. The LifeExplorer prototype enables biologists to explore in real time supramolecular structures from various models (simple spatial modelling, cryoelectron 3D reconstruction, docking,...). An annotation tool enables to organize and share information about assemblies. Current development focus on a knowledge repository linking existing databases (structures, papers,...) with visual representation.