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Miriah Meyer (Harvard University, Cambridge, United States of America)In our research we take a user-centered design approach to developing visualizations that enable scientific discovery. This interdisciplinary approach relies on both a detailed understanding of the needs of and close collaboration with domain scientists to guide the design of algorithms, visual encodings, and interaction mechanisms. Five stages define our research method for developing visualization systems: understand the scientific questions, experimental measurements, and the computational constraints; abstract these questions, measurements, and constraints into tasks, data types, and requirements; design a visualization system to support the tasks, data, and requirements; implement the system; and validate the effectiveness of the system for enabling scientific discovery. We showcase two tools developed using this methodology. The first tool, called MizBee, visualizes conserved syntenic data across a range of scales, from the genome down to the features. And the second tool, called Pathline, compares time-course gene expression data over multiple species and across multiple molecular pathways.