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Marc Baaden (Laboratoire de Biochimie Théorique, Paris, France)Cations bound to DNase I attract DNA for binding. The enzyme interface is pre-organized by calcium and magnesium ions occupying four binding sites shown as red spheres. DNA is shown in blue color and DNase in green. The molecule renderings were produced with VMD. The background image represents Staphylococcus aureus bacteria and is provided by CDC/Matthew J. Arduino, DRPH. Photo Credit: Janice Haney Carr. More details in Gueroult et al: How cations can assist DNase I in DNA binding and hydrolysis, PLoS Comp Bio 6, 2010, e1001000.