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Christian Stolte & Sean O’Donoghue (CSIRO Mathematics, Informatics & Statistics, Sydney, Australia)This project aims to improve the user experience for two bioinformatics tools – SRS 3D and Reflect. SRS 3D (http://srs3d.org) is a system that integrates 3D structures with sequences as well as sequence features (e.g., SNPs, posttranslational modification sites, domains, exons, etc.), with the goal of making macromolecular structures accessible and useable by biochemists and molecular biologists. Reflect (http://reflect.ws) was designed to be a simple and useful tool to helps life scientists use literature more effectively. In any web page, it tags protein, gene, and chemical names, and provides popups that give easy access to further details. We have started a new project to improve the usefulness and appeal of Reflect and SRS 3D by applying principles of graphics design, data visualization, colour theory, and usability.