Getting poster data...
Kenneth Sabir, Sean O’Donoghue, Christian Stolte, Nelson Perdigão, Vivian Ho, Venkata P. Satagopam, Maria Kalemanov, David Ma, Burkhard Rost, Andrea Schafferhans (CSIRO (Australia), Garvan Inst. (Australia), TUM (Germany), Tech. U. Lisbon (Portugal), U. Luxembourg (Luxembourg) U. Sydney (Australia))Compare the ca. 32 Million protein sequences deposited in UniProt with the fewer than 90,000 solved structures in PDB, and you realize they constitute only 0.28%! Nevertheless, for about half of all proteins, some three-dimensional (3D) structural information is available, since they are significantly similar to proteins with known 3D structure (Schafferhans et al., 2003). However, many scientists fail to benefit from this information because it is difficult to access and use. Out of this need was born SRS 3D, a module of SRS (Etzold et al., 1996), that allows users to easily and rapidly find all related structures for a given target sequence. Structures can then be viewed together with sequences, alignments and sequence features. Over the course of the last year, we set out to update, redesign and extend this service, which we plan to present under the name Aquaria.