Getting poster data...
Arnaud Ceol and Heiko Muller (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Via Adamello 16, 20139 Milan, Italy)With the advent of high throughput genomics, integration of network and structural biology approaches with project-based data-analysis pipelines represents a major challenge. Disease networks permit identifying connections between disease causing gene defects and mapping genomic regions to structured networks allows data-driven hypothesis generation about mutations that are likely to have edgetic effects. We have integrated the most recent standards and resources for network and structural biology into a plugin from the Integrated Genome Browser (IGB). The plugin maps genomic regions, for instance genes or mutations, to molecular network and interaction structures, and identifies those which lie at the interface between the product of the gene and either a protein, DNA, RNA or a small molecule. The results are visualized in genome tracks that enable the comparison of contact residues between interactions partners or between gene transcripts.