Getting poster data...
Maria Voigt, David S. Goodsell (RCSB Protein Data Bank, Rutgers, The State University of New Jersey Center for Integrative Proteomics Research 174 Frelinghuysen Rd Piscataway, NJ 08854-8076)During infection by HIV, three enzymes play essential roles in the life cycle of the virus. Reverse transcriptase (orange, top) copies the viral RNA genome and makes a DNA copy. Integrase (magenta, middle) inserts the viral DNA into the cell’s DNA. HIV protease (blue, bottom) is needed at the last steps of the viral life cycle to cut HIV proteins into their functional parts. Still images taken from animations from an educational film for medical students describing the HIV life cycle and its relation to HIV treatments. The animations are created based on atomic structures of different states of the enzymes from the RCSB PDB. [DBI-133841]