Getting poster data...
David Bouvier and Luis Salamanca. (Luxembourg Centre of Systems Biomedicine, University of Luxembourg, Belval, Luxembourg)Nowadays, drawings of the pioneer histologist Santiago Ramon y Cajal still served as references to understand the cellular complexity of the human brain and its alteration in disease. However the development of novel microscopy techniques has considerably improved the quality and the level of detail for visualizing the brain cells organizations and changes. In the current image we depict this evolution, as we incorporate traditional both ink drawings, that captured everything the eye could reach through a low-resolution microscope, and modern three-dimensional high-resolution images acquired with a confocal microscope. The art poster recalls the scientific ones and illustrates the death of a human hippocampal neuron, implicated in memory processes, and engulfed by a cluster of voracious microglia observed in a post-mortem brain sample of an Alzheimer’s Disease patient.