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Jieyi Zhao, Lingxi Zhou, Guocai Chen, Hua Xu, Jijun Tang, W. Jim Zheng (University of Texas Health Science Center at Houston)Built upon our first model-view framework of 3D eukaryotic genomes, we integrated various genomic databases to provide a multi-scale genome information visualization system to explore and navigate eukaryotic genome in 3-dimension. The new system, iGenome3D, provides a wide spectrum of tools, ranging from model construction to spatial analysis, to decipher the relationships between 3D conformation of the genome and its functional implication. The incorporation of literature allows users to quickly identify key features from PubMed abstracts for genes in the displayed 3D genome structure. The seamless integration of UCSC Genome Browser allows genetic and epigenetic features from the 2D browser to be visualized in 3D genome structure. iGenome3D can also output 3D genome model in various forms, including one that allows these models to be explored in modern virtual reality environments such as Oculus. Eukaryotic genomes can be analyzed from a completely new angle in iGenome3D that enables researchers to make new discoveries from a truly multi-scale exploration.