Getting poster data...
Andrew Burgess, Jenny Vuong, Samuel Rogers, Marcos Malumbres, Seán I. O’Donoghue (Garvan Institute of Medical Research. 370 Victoria Street, Darlinghurst, NSW 2010)Correct division of a cell into two identical daughter cells is essential for life, with perturbations strongly linked with multiple disease states including cancer. The final stage of cell division, mitosis, is driven by tightly ordered phosphorylation and subsequent dephosphorylation, occurring on over 30,000 phosphorylation sites, on more than 7000 proteins. The coordination on such a magnitude of substrates requires a tight, interdependent balance in kinase, and phosphatase activity. This activity coordinates phosphorylation in both space and time guaranteeing that the events of mitosis occur in the correct sequential order, maintaining genomic stability. Within this SnapShot we have visually depicted the major phosphorylation events in a temporal order, connected to the kinases and phosphatases that control them. The SnapShot uses an innovative ‘cirtangle’ layout to depict the latest multidimensional datasets, from both traditional biochemical and mass spectrometry studies. This work is a visually rich representation of the main phospho-signaling events in mitosis, and a vital compendium of knowledge for both experts and novices in the field of mitosis.