Getting poster data...
Benedetta Frida Baldi, Kenny Sabir, Sean O'Donoghue (The Garvan Institute of Medical Research, Darlinghurst, NSW; CSIRO-Data61,Eveleigh, NSW )Advances in chromosome conformation capture technologies reveal, that highly organized three dimensional (3D) arrangement of chromosomes underpin the structural and functional basis of the genome. However, visualisation of 3D spatial organization of chromosomes with epigenome data remains a significant challenge. We developed Rondo - a web-based, interactive tool for fast, intuitive exploration of chromatin interaction data in the context of genomic and epigenetic features. Rondo uses novel ‘spatial connectivity maps’ to allow fast, intuitive exploration of 16 published Hi-C datasets, plus a novel set of ‘Quasi-Universal’ spatial connections common across 5 human cell-lines. Rondo simplifies the process of gaining insight into genomic and epigenomic processes by allowing any molecular biologist to use Hi-C data to gain insights into genomic processes. Currently, the Quasi-Universal dataset comprises 38,482 conserved chromosomal interactions across 5 cell types. These data are a powerful instrument to study high-order genome structure, required for normal cell function and opening a whole new way of looking at these data, similarly to how the concept of housekeeping genes change