Getting poster data...
Anna Hupalowska (University of Cambridge, United Kingdom)The implantation stage is a crucial time in the embryo’s development. At this stage mammalian embryo undergoes a series of morphogenetic changes leading to a developmental transition from the pre-implantation blastocyst into the post-implantation egg cylinder. In this model pluripotent cells that will give rise to the foetus self-organize into a polarized 3D rosette-like structure that initiates egg cylinder formation. As the rosette develops further, the apical constriction leads to a lumen formation at the center of the rosette that eventually becomes the cavity where eventually the whole foetus is suspended and carefully protected. The coordination amongst the multiple cells at the implantation stage is crucial. The coming together of cells into this single rosette structure ensures that only one lumen is created and the whole embryo develops normally. These morphogenetic changes that are crucial for mammalian embryo development are presented as an analogy to synchronized swimming. If the erratically arranged swimmers come together to form a rosette, they can easily form an elegant structure with a hole in the centre.