Getting poster data...
Florian Gnad, Bin Zhang, Vidhisha Nandhikonda, Beth Murray, Jon M. Kornhauser, Vaughan Latham, Elzbieta Skrzypek, Peter V. Hornbeck (Cell Signaling Technology, Danvers, USA)Signaling in the cell is primarily mediated by small chemical changes on the surface of proteins called posttranslational modifications (PTMs). PhosphoSitePlus (www.phosphosite.org) is the most comprehensive resource for the study of PTMs, providing unique insight into cellular communication that controls all aspects of growth and development. Since perturbations of PTM-mediated signaling, like genetic mutations, can cause cancer and other diseases, we integrated oncogenic mutations from thousands of tumors and disease associated genetic variations in the human population into PhosphoSitePlus. To better comprehend the relationship and cooccurence of PTMs sites and mutations, we developed an interactive protein viewer (‘lollipop plot’) allowing the visualization of protein domains, protein sequence, PTMs, and mutations along with quantitative information including mutation frequencies and number of scientific studies showing evidence for given PTMs. We hope that the new visualization tool enables the scientific community to explore and discover previously unknown relationships between the worlds of PTMs and disease mutations leading to new therapeutic treatments or biomarkers.